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Evaluating Medication Response in ADHD

Cognitive, Behavioral, and Single-Subject Methodology

James B. Hale is an assistant professor in the School of Psychology Program at Moorhead State University. His current research interests include the neuropsychology of learning disabilities and attention-deficit disorders. Address: James B. Hale, Department of Psychology, Moorhead State University, Moorhead, MN 56563.

Jo-Ann B. Hoeppner, PhD

Jo-Ann B. Hoeppner is director of the Evaluation Center, Developmental and Neuropsychological Services, Evanston Northwestern Healthcare. She is an adjunct assistant professor in Psychology at Northwestern University. Her research interests include learning disabilities and seizure disorders.

Mary Beth DeWitt, PhD

Mary Beth DeWitt is a pediatric psychologist at the Children's Medical Center in Dayton, Ohio. Her current interests include behavioral treatment, adaptation to chronic illness, and developmental disabilities.

Daniel L. Coury, MD

Daniel L. Coury is professor of clinical pediatrics at The Ohio State University. His interests include ADHD and psychopharma-cology in children.

David G. Ritacco

David G. Ritacco is an assistant professor in the Department of Pediatrics at Northwestern University Medical School. He practices child neurology at Children's Memorial Hospital in Chicago, with particular interests in neurobehavioral problems and visual perception.

Barbara Trommer

Barbara Trommer is assistant professor of pediatrics and neurology, Northwestern University Medical School. She is the director of the Neurophysiology Research Laboratory of the Evanston Northwestern Healthcare Research Institute, and neurologic consultant to the Evaluation Center for Learning, Evanston Hospital.

Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.

Journal of Learning Disabilities, Vol. 31, No. 6, 595-607 (1998)
DOI: 10.1177/002221949803100610


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