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Very-Low-Birthweight Infants at Seven Years

An Assessment of the Health and Neurodevelopmental Risk Conveyed by Chronic Lung Disease

Anita M. Farel, DrPH, is a clinical associate professor in the Department of Maternal and Child Health, School of Public Health. Her research interests are access to services for high-risk infants, and children with chronic health conditions and disabilities.

Stephen R. Hooper

Stephen R. Hooper, PhD, is an associate professor in the Department of Psychiatry, School of Medicine. He is also psychology section head and director of the Child and Adolescent Neuropsychology Consultation Program at the Clinical Center for the Study of Development and Learning. His research interests include the study of neuropsychological mechanism and outcomes in pediatric and developmental disorders.

Stuart W. Teplin

Stuart W. Teplin, MD, is an associate professor in the Department of Pediatrics, School of Medicine, and is pediatric section head at the Clinical Center for the Study of Development and Learning. His research interests are the development of visual impairment in young children, follow-up of preterm infants, and autism.

Marianna M. Henry

Marianna M. Henry, MD, is an associate professor of pediatrics in the Division of Pediatric Pulmonary Medicine and Allergy, School of Medicine. She is interested in factors that influence the growth of lung function in early childhood, including pre- and postnatal exposures, respiratory illness, and the development of allergy.

Ernest N. Kraybill

Ernest N. Kraybill, MD, is a professor of pediatrics, School of Medicine. His research interests are the physical and developmental outcomes of low-birthweight infants. Address: Anita M. Farel, Department of Maternal and Child Health, School of Public Health-CB #7400, University of North Carolina, Chapel Hill, NC 27599. All authors are on the faculty at the University of North Carolina at Chapel Hill.

To determine whether history of chronic lung disease (CLD) in children born at very low birthweight (VLBW) confers additional risk for impaired health, growth, and neurodevelopment, 17 VLBW children born in 1984 who had CLD (requiring supplemental oxygen more than 30 days after birth) in infancy and 28 VLBW children who did not have CLD were assessed at age 7 years. Assessments included a medical history, standard physical and neurological examinations, pulmonary-function tests, and tests of neuropsychological and psychoeducational functioning. Health status did not differ between the groups. In contrast, children with CLD did not perform as well in neuropsychological and psychoeducational assessments. Although CLD confers little added risk to health, it seems to add significantly to risks for poor school performance that are known to be associated with very low birthweight.

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