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Corpus Callosum Morphology in Attention Deficit-Hyperactivity Disorder: Morphometric Analysis of MRI
George W. Hynd
George W. Hynd is research professor of special education and psychology and director, Center for Clinical and Developmental Neuropsychology, University of Georgia, Athens. Address: George W. Hynd, Center for Clinicol ond Developmental Neuropsychology, Deportment of Speckal Educotion, EXC-Aderhold HoIL University of Georgio, Athens, GA 30602.
Margaret Semrud-Clikeman
Margaret Semrud-Clikeman is a Neuroscience Fellow in the Department of Psychiatry, Massachusetis General Hospital, Boston.
Alison R. Lorys
Alison R. Lorys is a child neuropsychologist at North Short University Hospital, Manhasset, New York.
Edward S. Novey
Edward S. Novey is medical director, Athens Magnetic Imaging, Athens, Georgia.
Deborah Eliopulos
Deborah Ellopulos is a radiologic technologist, Athens Magnetic Imaging, Athens, Georgia.
Heikki Lyytinen
Heikki Lyytinen is a senior scientist with the Finnish Academy of Science, Department of Psychology, University of Jyvaskyla, Jyvaskyla, Finland.
Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there is little direct evidence to reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared to nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study to determine whether correlated regional variation might exist in the corpus callosum of children with ADHD. While all MRI scans were judged to be clinically normal, morphometric analysis revealed that, compared to nondisabled controls, ADHD children had a smaller corpus callosum, particularly in the region of the genu and splenium, and in the area just anterior to the splenium. Interhemispheric fibers in these regions interconnect the left and right frontal, occipital, parietal, and posterior temporal regions. These results suggest that subtle differences may exist in the brains of children with ADHD and that deviations in normal corticogenesis may underlie the behavioral manifestations of this disorder.
Journal of Learning Disabilities, Vol. 24, No. 3,
141-146 (1991)
DOI: 10.1177/002221949102400302
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